منابع مشابه
Epigenetic rejuvenation
Induced pluripotent stem (iPS) cells have provided a rational means of obtaining histo-compatible tissues for 'patient-specific' regenerative therapies (Hanna et al. 2010; Yamanaka & Blau 2010). Despite the obvious potential of iPS cell-based therapies, there are certain problems that must be overcome before these therapies can become safe and routine (Ohi et al. 2011; Pera 2011). As an alterna...
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The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be reversed, restoring characteristics of youthfulness to aged cells and tissues. This Review focuses on the emerging biology of rejuvenation thro...
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Elderly people may remember the drug peddlers who frequented the noisy country markets when they were growing up. Even though it was difficult to trust the peddlers, it was even more difficult to resist the temptation to buy their goods. They volubly emphasized that their products could be a silver-bullet potion for rejuvenation. Attracted to such suspicious advertisements, more than a few gull...
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Standardization of mesenchymal stromal cells (MSCs) remains a major obstacle in regenerative medicine. Starting material and culture expansion affect cell preparations and render comparison between studies difficult. In contrast, induced pluripotent stem cells (iPSCs) assimilate toward a ground state and may therefore give rise to more standardized cell preparations. We reprogrammed MSCs into i...
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We present a framework of adaptive estimation and rejuvenation of software system performance in the presence of aging sources. The framework specifies that a degradation model not only describe an aging process but also enable the adaptation of model-based performance estimates to on-line measurements of data pertaining to the aging process. The adaptive estimation uses model-based a priori es...
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ژورنال
عنوان ژورنال: Genes to Cells
سال: 2012
ISSN: 1356-9597,1365-2443
DOI: 10.1111/j.1365-2443.2012.01595.x